The CSK Polyclonal Antibody (CAB0666) is a valuable tool for researchers studying CSK, a key regulator of cell signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CSK protein, this antibody enables the detection and analysis of CSK expression in various cell types, making it ideal for studies in signal transduction pathways and cellular regulation.CSK, also known as C-terminal Src kinase, plays a crucial role in the negative regulation of protein tyrosine kinases, including Src family kinases.
Dysregulation of CSK activity has been implicated in various diseases, including cancer and immune disorders. By studying the function of CSK, researchers can gain insights into its role in cellular processes and potentially identify new therapeutic targets for disease intervention. The CSK Polyclonal Antibody is a valuable tool for advancing research in these areas.
Product Name:
CSK Rabbit Monoclonal Antibody
SKU:
CAB0666
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CSK (P41240).
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1445
Clone Number:
ARC1835
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CSK Rabbit mAb (CAB0666) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
