The CSH2 Polyclonal Antibody (PAC051450) is a valuable tool for researchers studying the CSH2 protein, which is known for its role in regulating cell growth and proliferation. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications. By binding to the CSH2 protein, this antibody enables researchers to detect and analyze CSH2 expression in various cell types.CSH2, also known as chorionic somatomammotropin hormone 2, is involved in a variety of cellular processes, including promoting cell division and differentiation.
Its significance in cell growth regulation makes it a promising target for studying cancer and other proliferative disorders. By understanding the function of CSH2, researchers can potentially develop targeted therapies for these conditions.Overall, the CSH2 Polyclonal Antibody is a valuable tool for researchers interested in studying the role of CSH2 in cellular growth and proliferation. Its high reactivity and specificity make it a reliable option for Western blot analyses in immunology and cancer research.
Western Blot. Positive WB detected in: Mouse heart tissue, Mouse kidney tissue. All lanes: CSH2 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 25, 19, 14 kDa. Observed band size: 25 kDa..
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO51450 at dilution of 1:100.
Background:
Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.
CSH1: Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization. Belongs to the somatotropin/prolactin family.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 17q24.2Cellular Component: extracellular regionMolecular Function: metal ion binding; hormone activity
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008]
