CSGALNACT2 Antibody (PACO25985)
- SKU:
- PACO25985
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CSGALNACT2 Antibody (PACO25985)
The CS GalNAcT2 Polyclonal Antibody (PAC025985) is a valuable tool for researchers studying CS GalNAcT2 protein, an important enzyme involved in the biosynthesis of chondroitin sulfate (CS) chains. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.CS GalNAcT2 is an essential enzyme in the glycosaminoglycan biosynthetic pathway, playing a crucial role in the modification of CS chains that are essential for cell signaling and extracellular matrix organization. By specifically targeting CS GalNAcT2, researchers can investigate its function in various cell types and tissues, providing insights into the molecular mechanisms underlying glycosaminoglycan biosynthesis.
The CS GalNAcT2 Polyclonal Antibody is a valuable tool for studying the role of CS GalNAcT2 in various physiological and pathological conditions, such as development, tissue repair, and cancer progression. Understanding the function of this enzyme may lead to the development of novel therapeutic strategies targeting glycosaminoglycan biosynthesis pathways in diseases related to aberrant CS chain modifications.
| Antibody Name: | CSGALNACT2 Antibody (PACO25985) |
| Antibody SKU: | PACO25985 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Chondroitin sulfate N-acetylgalactosaminyltransferase 2 protein (33-270AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: CSGALNACT2 antibody at 4µg/ml Lane 1: K562 whole cell lysate Lane 2: 293T whole cell lysate Lane 3: Jurkat whole cell lysate Lane 4: PC-3 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 63, 39 kDa Observed band size: 63 kDa . |
 | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO25985 at dilution of 1:100. |
| Background: | Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid, (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. |
| Synonyms: | Chondroitin sulfate N-acetylgalactosaminyltransferase 2 (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2) (Beta4GalNAcT-2) (GalNAcT-2), CSGALNACT2, CHGN2 GALNACT2 |
| UniProt Protein Function: | GALNACT2: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Belongs to the chondroitin N- acetylgalactosaminyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral; EC 2.4.1.174 Chromosomal Location of Human Ortholog: 10q11.21 Cellular Component: Golgi membrane; membrane; integral to Golgi membrane Molecular Function:acetylgalactosaminyltransferase activity; metal ion binding; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Biological Process: chondroitin sulfate metabolic process; dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; proteoglycan biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; pathogenesis; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; dermatan sulfate proteoglycan biosynthetic process |
| NCBI Summary: | This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q8N6G5 |
| NCBI GenInfo Identifier: | 60391915 |
| NCBI Gene ID: | 55454 |
| NCBI Accession: | Q8N6G5.1 |
| UniProt Secondary Accession: | Q8N6G5,Q6MZJ5, Q6MZP6, Q8TCH4, Q9P1I6, B3KWL7, |
| UniProt Related Accession: | Q8N6G5 |
| Molecular Weight: | 38,440 Da |
| NCBI Full Name: | Chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| NCBI Synonym Full Names: | chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| NCBI Official Symbol: | CSGALNACT2Â Â |
| NCBI Official Synonym Symbols: | CHGN2; PRO0082; GALNACT2; GALNACT-2Â Â |
| NCBI Protein Information: | chondroitin sulfate N-acetylgalactosaminyltransferase 2; beta 4 GalNAcT-2; chondroitin beta1,4 N-acetylgalactosaminyltransferase 2 |
| UniProt Protein Name: | Chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| UniProt Synonym Protein Names: | Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2; Beta4GalNAcT-2; GalNAcT-2 |
| Protein Family: | Chondroitin sulfate N-acetylgalactosaminyltransferase |
| UniProt Gene Name: | CSGALNACT2Â Â |
| UniProt Entry Name: | CGAT2_HUMAN |
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