CSGALNACT2 Antibody (PACO15718)
- SKU:
- PACO15718
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CSGALNACT2 Antibody (PACO15718)
The CSGALNACT2 Polyclonal Antibody (PAC015718) is a valuable tool for researchers studying CSGALNACT2, a key enzyme involved in the biosynthesis of chondroitin sulfate proteoglycans. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications.CSGALNACT2 plays a crucial role in the regulation of chondroitin sulfate proteoglycan synthesis, which is essential for numerous biological processes including cell adhesion, migration, and signaling. Dysregulation of CSGALNACT2 has been linked to various diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases, making it a promising target for therapeutic development.
With the ability to specifically bind to CSGALNACT2 protein, this antibody enables researchers to detect and analyze CSGALNACT2 expression levels in different cell types, providing valuable insights into its functional role in health and disease. Its application in immunology and cancer research makes it a versatile tool for investigating the mechanisms underlying these conditions and developing targeted treatment strategies.
| Antibody Name: | CSGALNACT2 Antibody (PACO15718) |
| Antibody SKU: | PACO15718 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human CSGALNACT2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO15718(CSGALNACT2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. A related pseudogene has been identified on chromosome X. Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid, (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. |
| Synonyms: | chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| UniProt Protein Function: | GALNACT2: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Belongs to the chondroitin N- acetylgalactosaminyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral; EC 2.4.1.174 Chromosomal Location of Human Ortholog: 10q11.21 Cellular Component: Golgi membrane; membrane; integral to Golgi membrane Molecular Function:acetylgalactosaminyltransferase activity; metal ion binding; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Biological Process: chondroitin sulfate metabolic process; dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; proteoglycan biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; pathogenesis; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; dermatan sulfate proteoglycan biosynthetic process |
| NCBI Summary: | This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q8N6G5 |
| NCBI GenInfo Identifier: | 60391915 |
| NCBI Gene ID: | 55454 |
| NCBI Accession: | Q8N6G5.1 |
| UniProt Secondary Accession: | Q8N6G5,Q6MZJ5, Q6MZP6, Q8TCH4, Q9P1I6, B3KWL7, |
| UniProt Related Accession: | Q8N6G5 |
| Molecular Weight: | 38,440 Da |
| NCBI Full Name: | Chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| NCBI Synonym Full Names: | chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| NCBI Official Symbol: | CSGALNACT2Â Â |
| NCBI Official Synonym Symbols: | CHGN2; PRO0082; GALNACT2; GALNACT-2Â Â |
| NCBI Protein Information: | chondroitin sulfate N-acetylgalactosaminyltransferase 2; beta 4 GalNAcT-2; chondroitin beta1,4 N-acetylgalactosaminyltransferase 2 |
| UniProt Protein Name: | Chondroitin sulfate N-acetylgalactosaminyltransferase 2 |
| UniProt Synonym Protein Names: | Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2; Beta4GalNAcT-2; GalNAcT-2 |
| Protein Family: | Chondroitin sulfate N-acetylgalactosaminyltransferase |
| UniProt Gene Name: | CSGALNACT2Â Â |
| UniProt Entry Name: | CGAT2_HUMAN |
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