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CSGALNACT2 Antibody (PACO04700)

SKU:
PACO04700
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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CSGALNACT2 Antibody (PACO04700)

The CSGALNACT2 Polyclonal Antibody (PAC004700) is a valuable tool for researchers investigating the role of CSGALNACT2, an enzyme involved in the biosynthesis of chondroitin sulfate proteoglycans. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CSGALNACT2 protein, this antibody enables researchers to detect and analyze the enzyme in various cell types, making it ideal for studies in glycobiology and extracellular matrix research.

CSGALNACT2 is an essential enzyme in the biosynthesis of chondroitin sulfate proteoglycans, which play crucial roles in cell adhesion, signaling, and matrix organization. Dysregulation of CSGALNACT2 has been implicated in various diseases, including cancer and inflammatory conditions. Understanding the function of CSGALNACT2 is key to unraveling its role in these pathological processes and developing potential therapeutic interventions targeting this enzyme.

Antibody Name:CSGALNACT2 Antibody
Antibody SKU:PACO04700
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human CsGalNAcT-2.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CSGALNACT2; CHGN2; GALNACT2; Chondroitin sulfate N-acetylgalactosaminyltransferase 2; Chondroitin beta-1; 4-N-acetylgalactosaminyltransferase 2; Beta4GalNAcT-2; GalNAcT-2
UniProt Protein Function:GALNACT2: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Belongs to the chondroitin N- acetylgalactosaminyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral; EC 2.4.1.174

Chromosomal Location of Human Ortholog: 10q11.21

Cellular Component: Golgi membrane; membrane; integral to Golgi membrane

Molecular Function:acetylgalactosaminyltransferase activity; metal ion binding; glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity

Biological Process: chondroitin sulfate metabolic process; dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; chondroitin sulfate biosynthetic process; glycosaminoglycan metabolic process; proteoglycan biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; pathogenesis; chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; dermatan sulfate proteoglycan biosynthetic process

NCBI Summary:This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. The encoded protein is involved in elongation during chondroitin sulfate synthesis. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Dec 2012]
UniProt Code:Q8N6G5
NCBI GenInfo Identifier:60391915
NCBI Gene ID:55454
NCBI Accession:Q8N6G5.1
UniProt Secondary Accession:Q8N6G5,Q6MZJ5, Q6MZP6, Q8TCH4, Q9P1I6, B3KWL7,
UniProt Related Accession:Q8N6G5
Molecular Weight:38,440 Da
NCBI Full Name:Chondroitin sulfate N-acetylgalactosaminyltransferase 2
NCBI Synonym Full Names:chondroitin sulfate N-acetylgalactosaminyltransferase 2
NCBI Official Symbol:CSGALNACT2  
NCBI Official Synonym Symbols:CHGN2; PRO0082; GALNACT2; GALNACT-2  
NCBI Protein Information:chondroitin sulfate N-acetylgalactosaminyltransferase 2; beta 4 GalNAcT-2; chondroitin beta1,4 N-acetylgalactosaminyltransferase 2
UniProt Protein Name:Chondroitin sulfate N-acetylgalactosaminyltransferase 2
UniProt Synonym Protein Names:Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 2; Beta4GalNAcT-2; GalNAcT-2
Protein Family:Chondroitin sulfate N-acetylgalactosaminyltransferase
UniProt Gene Name:CSGALNACT2  
UniProt Entry Name:CGAT2_HUMAN

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