The CSF1R Polyclonal Antibody (CAB3019) is crafted for research purposes involving CSF1R, a cell surface receptor known for its role in regulating immune responses and inflammation. This antibody, produced through the immunization of rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CSF1R protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent tool for studies in immunology and cancer research.CSF1R, also known as colony-stimulating factor 1 receptor, is a crucial player in immune system regulation and is implicated in various diseases, including cancer and inflammatory conditions.
Understanding the functions and mechanisms of CSF1R is essential for advancing research and developing targeted therapies for diseases where its dysregulation is a contributing factor. The CSF1R Polyclonal Antibody provides researchers with a valuable tool to explore the role of CSF1R in immune responses and disease pathogenesis, ultimately driving advancements in therapeutic strategies.
Product Name:
CSF1R Rabbit Polyclonal Antibody
SKU:
CAB3019
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 873-972 of human CD115/CSF-1R (NP_005202.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
108kDa
Observed MW:
150-190kDa
The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
Purification Method:
Affinity purification
Gene ID:
1436
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD115/CSF-1R Rabbit pAb (CAB3019) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
