CSF1R Antibody (PACO25977)
- SKU:
- PACO25977
- Product Type:
- Antibody
- Reactivity:
- Cat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
CSF1R Antibody (PACO25977)
The CSF1R Monoclonal Antibody (PAC025977) is a valuable tool for researchers studying CSF1R, a cell surface receptor involved in the regulation of macrophage differentiation and function. This antibody, produced from a hybridoma cell line, shows high specificity and sensitivity for human samples, making it ideal for use in various research applications such as Western blotting and immunohistochemistry. By binding to the CSF1R protein, this antibody enables precise detection and analysis of this crucial receptor in different cell types.CSF1R, also known as Colony Stimulating Factor 1 Receptor, is essential for the development and maintenance of macrophages, key players in the immune response and tissue homeostasis. Dysregulation of CSF1R signaling has been implicated in various diseases, including cancer, inflammatory disorders, and neurological conditions.
By studying the role of CSF1R in disease pathogenesis, researchers can gain insights into potential therapeutic targets for these conditions.The CSF1R Monoclonal Antibody (PAC025977) provides researchers with a reliable tool to investigate the function and expression of CSF1R in different biological contexts, paving the way for advancements in immunology, oncology, and other related fields. Its high specificity and sensitivity make it a valuable asset for research aimed at understanding the complex mechanisms underlying macrophage biology and immune system regulation. Unlock the potential of CSF1R research with this high
| Antibody Name: | CSF1R Antibody (PACO25977) |
| Antibody SKU: | PACO25977 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Felis silvestris catus |
| Immunogen: | Recombinant Felis silvestris catus Macrophage colony-stimulating factor 1 receptor protein (20-514AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor |
| Synonyms: | Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115), CSF1R, FMS |
| UniProt Protein Function: | Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P13369 |
| NCBI GenInfo Identifier: | 57163771 |
| NCBI Gene ID: | 493706 |
| NCBI Accession: | NP_001009231.1 |
| UniProt Secondary Accession: | P13369 |
| UniProt Related Accession: | P13369 |
| Molecular Weight: | 108,507 Da |
| NCBI Full Name: | macrophage colony-stimulating factor 1 receptor |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | CSF1RÂ Â |
| NCBI Official Synonym Symbols: | CSF1; M-CSF; CSF-1R; M-CSF-RÂ Â |
| NCBI Protein Information: | macrophage colony-stimulating factor 1 receptor; CSF-1 receptor; CSF-1-R; c-fms; proto-oncogene c-Fms; proto-oncogene fms |
| UniProt Protein Name: | Macrophage colony-stimulating factor 1 receptor |
| UniProt Synonym Protein Names: | CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115 |
| Protein Family: | |
| UniProt Gene Name: | CSF1RÂ Â |
| UniProt Entry Name: | CSF1R_FELCA |
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