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Csf1 Antibody (PACO32460)

SKU:
PACO32460
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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Csf1 Antibody (PACO32460)

The CSF1 Antibody (PAC032460) is a valuable tool for researchers studying CSF1, a cytokine involved in the regulation of monocyte and macrophage differentiation, proliferation, and survival. This polyclonal antibody is produced in rabbits and is highly specific for human samples, making it ideal for use in a variety of research applications, including Western blot analysis.CSF1, also known as colony-stimulating factor 1, plays a crucial role in the immune system by promoting the development and function of monocytes and macrophages. Dysregulation of CSF1 signaling has been implicated in a variety of diseases, including cancer, autoimmune disorders, and inflammatory conditions.

By studying the expression and activity of CSF1 using this antibody, researchers can gain valuable insights into the role of CSF1 in these diseases and potentially identify new therapeutic targets.Overall, the CSF1 Antibody (PAC032460) is a powerful tool for researchers investigating the role of CSF1 in immune regulation and disease pathogenesis. Its high specificity and reactivity with human samples make it a reliable choice for studies in immunology, oncology, and other related fields.

Antibody Name:Csf1 Antibody (PACO32460)
Antibody SKU:PACO32460
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Macrophage colony-stimulating factor 1 protein (33-262AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Synonyms:Macrophage colony-stimulating factor 1 (CSF-1) (MCSF) [Cleaved into: Processed macrophage colony-stimulating factor 1], Csf1, Csfm
UniProt Protein Function:M-CSF: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cytokine

Cellular Component: extracellular space; membrane; perinuclear region of cytoplasm; extracellular region; integral to membrane; plasma membrane; receptor complex

Molecular Function:protein binding; protein homodimerization activity; growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding

Biological Process: positive regulation of monocyte differentiation; ossification; macrophage differentiation; immune system process; positive regulation of osteoclast differentiation; positive regulation of cellular protein metabolic process; reproductive developmental process; positive regulation of odontogenesis of dentine-containing teeth; positive regulation of multicellular organism growth; osteoclast differentiation; odontogenesis; cell proliferation; positive regulation of mononuclear cell proliferation; homeostasis of number of cells within a tissue; positive regulation of protein kinase activity; positive regulation of cell proliferation; innate immune response; positive regulation of Ras protein signal transduction; regulation of ossification; inflammatory response; positive regulation of macrophage differentiation; positive regulation of cell-matrix adhesion; positive regulation of cell migration

UniProt Code:P07141
NCBI GenInfo Identifier:1345843
NCBI Gene ID:12977
NCBI Accession:P07141.2
UniProt Secondary Accession:P07141,Q3U395, Q8R3C8,
UniProt Related Accession:P07141
Molecular Weight:29,353 Da
NCBI Full Name:Macrophage colony-stimulating factor 1
NCBI Synonym Full Names:colony stimulating factor 1 (macrophage)
NCBI Official Symbol:Csf1  
NCBI Official Synonym Symbols:op; Csfm; MCSF; C87615  
NCBI Protein Information:macrophage colony-stimulating factor 1; osteopetrosis
UniProt Protein Name:Macrophage colony-stimulating factor 1
Protein Family:C-C motif chemokine
UniProt Gene Name:Csf1  
UniProt Entry Name:CSF1_MOUSE

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