The Cryptochrome 2 Polyclonal Antibody (CAB6891) is a valuable tool for researchers studying the role of Cryptochrome 2, a protein involved in circadian rhythm regulation and DNA repair processes. This antibody, produced in rabbits, has high specificity for Cryptochrome 2 and is validated for use in Western blot applications. By binding to Cryptochrome 2, this antibody enables the detection and analysis of the protein in various cell types, making it ideal for investigations in chronobiology and DNA damage response pathways.Cryptochrome 2 is a key player in the circadian clock system, influencing the timing of physiological processes and behaviors in response to light cues.
Additionally, it plays a role in repairing DNA damage caused by exposure to UV radiation or other genotoxic stressors. Research on Cryptochrome 2 has implications for understanding diseases linked to circadian disruption, such as sleep disorders, metabolic disorders, and cancer.In summary, the Cryptochrome 2 Polyclonal Antibody is a valuable research tool for investigating the functions and mechanisms of Cryptochrome 2 in circadian rhythm regulation and DNA repair pathways. Its specificity and reliability make it an essential component of studies aiming to unravel the complex roles of Cryptochrome 2 in health and disease.
Product Name:
CRY2 Rabbit Polyclonal Antibody
SKU:
CAB6891
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human CRY2 (NP_066940.3).
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1408
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CRY2 Rabbit pAb (CAB6891) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
