null

CRYBB1 Rabbit Polyclonal Antibody (CAB2590)

SKU:
CAB2590
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

CRYBB1 Rabbit Polyclonal Antibody (CAB2590)

The Crybb1 Polyclonal Antibody (CAB2590) is a research tool designed for studying Crybb1, a protein that plays a crucial role in the lens of the eye. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the Crybb1 protein, researchers can detect and analyze its expression in various cell types, making it an ideal tool for studies related to eye development and diseases affecting the lens.

Crybb1 is known for its importance in maintaining lens transparency and proper vision. Mutations in the Crybb1 gene have been linked to cataracts and other eye disorders, making it a target for research aimed at understanding the underlying mechanisms of these conditions. By using the Crybb1 Polyclonal Antibody, researchers can further explore the function of Crybb1 and its role in eye health, potentially leading to new insights and therapeutic approaches for eye diseases.

Product Name:CRYBB1 Rabbit Polyclonal Antibody
SKU:CAB2590
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-252 of human CRYBB1 (NP_001878.1).
Sequence:MSQA AKAS ASAT VAVN PGPD TKGK GAPP AGTS PSPG TTLA PTTV PITS AKAA ELPP GNYR LVVF ELEN FQGR RAEF SGEC SNLA DRGF DRVR SIIV SAGP WVAF EQSN FRGE MFIL EKGE YPRW NTWS SSYR SDRL MSFR PIKM DAQE HKIS LFEG ANFK GNTI EIQG DDAP SLWV YGFS DRVG SVKV SSGT WVGY QYPG YRGY QYLL EPGD FRHW NEWG AFQP QMQS LRRL RDKQ WHLE GSFP VLAT EPPK
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:CATCN3; CTRCT17; CRYBB1
Positive Sample:Mouse eye
Conjugate:Unconjugated
Calculated MW:28kDa
Observed MW:28kDa

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, undergoes extensive cleavage at its N-terminal extension during lens maturation. It is also a member of a gene cluster with beta-A4, beta-B2, and beta-B3.

Purification Method:Affinity purification
Gene ID:1414
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using CRYBB1 Rabbit pAb (CAB2590) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

Related Products