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CRYAA Monoclonal Antibody [Pc9F2AT] (CPAB0279)

SKU:
CPAB0279
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
Pc9F2AT
Applications:
WB
ELISA
$179
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Description

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CRYAA Monoclonal Antibody [Pc9F2AT] (CPAB0279)

The Cryaa Polyclonal Antibody (CPAB0279) is a vital tool for researchers studying Cryaa, a key protein involved in eye development and function. This antibody, generated in rabbits, exhibits strong reactivity with human samples and is validated for use in a variety of applications, including Western blot and immunohistochemistry. By specifically binding to the Cryaa protein, this antibody enables precise detection and analysis in different cell types, making it an invaluable resource for studies in ophthalmology and vision research.

Cryaa, also known as Alpha-crystallin A chain, is essential for maintaining lens transparency and preventing cataract formation. Dysregulation of Cryaa has been implicated in various eye disorders, making it a promising target for therapeutic interventions aimed at preserving vision and treating conditions such as age-related macular degeneration and diabetic retinopathy. By elucidating the role of Cryaa in eye health, researchers can pave the way for innovative treatments and preventative strategies in the field of ophthalmology.

Product Name:CRYAA Antibody
Product Sku:CPAB0279
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CRYAA mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CRYAA amino acids 1-173 purified from Ecoli.
Clone:Pc9F2AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:CRYAA antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:Alpha crystallins are composed of two gene products ; alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20). They act as molecular chaperones and hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional function of -crystallins are an autokinase activity and participation in the intracellular architecture. The expression of alpha-A is preferentially restricted to the lens cell.
Synonyms:CRYA1, HSPB4, CRYAA, Crystallin Alpha A, Alpha-crystallin A chain, Heat shock protein beta-4.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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