Anti-CRY2 Antibody (CAB17465)
- SKU:
- CAB17465
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-CRY2 Antibody (CAB17465)
The Cry2 Polyclonal Antibody (CAB17465) is a vital tool for research involving the Cry2 protein, a key component of the circadian clock implicated in regulating biological rhythms. This rabbit-raised antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the Cry2 protein, this antibody enables precise detection and analysis in various cell types, providing valuable insights into circadian biology and its impact on human health.The Cry2 protein plays a critical role in the regulation of the circadian clock, which synchronizes physiological processes with the 24-hour day-night cycle. Disruption of circadian rhythms has been linked to various health issues, including sleep disorders, metabolic disorders, and even cancer.
Studying the function of Cry2 is essential for understanding how the circadian clock influences these processes and for developing interventions to maintain or restore healthy rhythms.By utilizing the Cry2 Polyclonal Antibody (CAB17465) in your research, you can gain valuable insights into the role of Cry2 in circadian biology and its implications for human health. Whether investigating basic circadian mechanisms or exploring potential therapeutic targets for circadian-related disorders, this antibody is a powerful tool for advancing scientific understanding in the field.
| Antibody Name: | Anti-CRY2 Antibody |
| Antibody SKU: | CAB17465 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-266 of human CRY2 (NP_066940.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-266 of human CRY2 (NP_066940.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | PAPG TDSA SSVH WFRK GLRL HDNP ALLA AVRG ARCV RCVY ILDP WFAA SSSV GINR WRFL LQSL EDLD TSLR KLNS RLFV VRGQ PADV FPRL FKEW GVTR LTFE YDSE PFGK ERDA AIMK MAKE AGVE VVTE NSHT LYDL DRII ELNG QKPP LTYK RFQA IISR MELP KKPV GLVT SQQM ESCR AEIQ ENHD ETYG VPSL EELG FPTE GLGP AVWQ GGET EALA RLDK HLE |
| Gene ID: | 1408 |
| Uniprot: | Q49AN0 |
| Cellular Location: | |
| Calculated MW: | 60kDa/66kDa |
| Observed MW: | 67KDa |
 | `- CRY2 Polyclonal Antibody (CAB17465) |
| Synonyms: | CRY2, HCRY2, PHLL2 |
| Background: | This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014] |
| UniProt Protein Function: | CRY2: Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL. Belongs to the DNA photolyase class-1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Lyase Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: cytoplasm; extracellular region; nucleus Molecular Function:ubiquitin binding; protein binding; DNA binding; DNA (6-4) photolyase activity; damaged DNA binding; deoxyribodipyrimidine photo-lyase activity; blue light photoreceptor activity; single-stranded DNA binding; phosphatase binding Biological Process: circadian rhythm; photoreactive repair; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; regulation of circadian rhythm; protein-chromophore linkage; entrainment of circadian clock by photoperiod; blue light signaling pathway; negative regulation of phosphoprotein phosphatase activity; negative regulation of circadian rhythm; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q49AN0 |
| NCBI GenInfo Identifier: | 118572252 |
| NCBI Gene ID: | 1408 |
| NCBI Accession: | Q49AN0.2 |
| UniProt Secondary Accession: | Q49AN0,O75148, Q8IV71, B4DH32, B4DZD6, |
| UniProt Related Accession: | Q49AN0 |
| Molecular Weight: | |
| NCBI Full Name: | Cryptochrome-2 |
| NCBI Synonym Full Names: | cryptochrome circadian clock 2 |
| NCBI Official Symbol: | CRY2Â Â |
| NCBI Official Synonym Symbols: | HCRY2; PHLL2Â Â |
| NCBI Protein Information: | cryptochrome-2; growth-inhibiting protein 37; cryptochrome 2 (photolyase-like) |
| UniProt Protein Name: | Cryptochrome-2 |
| Protein Family: | Cryptochrome |
| UniProt Gene Name: | CRY2Â Â |
| UniProt Entry Name: | CRY2_HUMAN |
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