The Cry1 Polyclonal Antibody (CAB13666) is an essential tool for researchers studying Cry1, a protein involved in the circadian clock and light regulation pathways. This antibody, produced using rabbits, is highly specific to Cry1 and has been validated for use in Western blot applications. By binding to Cry1, this antibody allows for the detection and analysis of Cry1 protein levels in a variety of cell types, making it ideal for studies in chronobiology and neuroscience.Cry1 is a key component of the circadian clock, controlling the body's internal clock and coordinating various physiological and behavioral processes with the day-night cycle.
Dysregulation of Cry1 has been linked to sleep disorders, mood disorders, and metabolic abnormalities. Therefore, research on Cry1 can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of new treatments targeting the circadian system.By utilizing the Cry1 Polyclonal Antibody, researchers can enhance their understanding of Cry1 function and its role in circadian rhythm regulation. This antibody is a valuable tool for investigating the molecular mechanisms governing the circadian clock and may pave the way for new therapeutic interventions aimed at restoring proper circadian function.
Product Name:
CRY1 Rabbit Polyclonal Antibody
SKU:
CAB13666
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 496-586 of human CRY1 (NP_004066.1).
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness.
Purification Method:
Affinity purification
Gene ID:
1407
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Y79 cells, using CRY1 antibody (CAB13666) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
