The CRY1 Polyclonal Antibody (CAB13662) is a valuable tool for researchers studying CRY1, a key protein involved in the circadian clock system. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the CRY1 protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal choice for studies in chronobiology, neurology, and metabolism research.CRY1 is a critical component of the circadian clock system, responsible for regulating daily rhythms in processes such as sleep-wake cycles, hormone secretion, and metabolism.
Dysregulation of CRY1 has been linked to various health issues, including sleep disorders, metabolic disorders, and mood disorders. Research into the role of CRY1 can provide valuable insights into these conditions and potentially lead to the development of targeted therapies for circadian rhythm-related disorders.
Product Name:
CRY1 Rabbit Polyclonal Antibody
SKU:
CAB13662
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 496-586 of human CRY1 (NP_004066.1).
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness.
Purification Method:
Affinity purification
Gene ID:
1407
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CRY1 Rabbit pAb (CAB13662) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
