The CRX Polyclonal Antibody (CAB5719) is a valuable tool for researching the CRX protein, a key regulator of photoreceptor development and function. This antibody, produced in rabbits, is highly specific to human samples, making it ideal for use in Western blot applications. By binding to the CRX protein, researchers can detect and analyze its expression in various cell types, enabling insights into its roles in vision and retinal development.
CRX, also known as cone-rod homeobox protein, is essential for the differentiation and maintenance of photoreceptor cells in the retina. Mutations in the CRX gene are linked to various retinal disorders, including retinitis pigmentosa and cone-rod dystrophy. By studying CRX expression and function, researchers can gain a better understanding of these diseases and potentially identify new therapeutic targets for vision disorders.
Product Name:
CRX Rabbit Polyclonal Antibody
SKU:
CAB5719
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CRX (NP_000545.1).
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
1406
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse eye, using CRX antibody (CAB5719) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
