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CRTC2 Rabbit Polyclonal Antibody (CAB10682)

SKU:
CAB10682
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:CRTC2 Rabbit Polyclonal Antibody
SKU:CAB10682
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 16-126 of human CRTC2 (NP_859066.1).
Sequence:ASNP RKFS EKIA LQKQ RQAE ETAA FEEV MMDI GSTR LQAQ KLRL AYTR SSHY GGSL PNVN QIGS GLAE FQSP LHSP LDSS RSTR HHGL VERV QRDP RRMV SPLR RYTR HID
Tested Applications:WB ELISA
Recommended Dilution:WB,1:100 - 1:500
Synonyms:TORC2; TORC-2; CRTC2
Positive Sample:PC-3,293T
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:73kDa
Observed MW:73kDa

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.

Purification Method:Affinity purification
Gene ID:200186
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using CRTC2 antibody (CAB10682) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.

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