The CRMP2 Rabbit Monoclonal Antibody (CAB4411) is a vital tool for research involving CRMP2, a protein involved in various cellular processes, including neuronal development and axon guidance. This antibody is raised in rabbits and is highly specific and sensitive for detecting CRMP2 in human samples. It has been validated for use in Western blot, immunohistochemistry, and immunofluorescence applications, allowing for precise detection and analysis of CRMP2 expression in different cell types and tissues.CRMP2, also known as collapsin response mediator protein 2, is a key player in neurodevelopmental processes and has been implicated in neurological disorders such as Alzheimer's disease, schizophrenia, and epilepsy.
Understanding the role of CRMP2 in these conditions is crucial for developing targeted therapies and interventions. The CRMP2 Rabbit Monoclonal Antibody provides researchers with a reliable tool for exploring the functions and mechanisms of CRMP2 in both normal and pathological conditions, ultimately advancing our understanding of neurological disorders and potential treatment strategies.
Product Name:
CRMP2/DPYSL2 Rabbit Monoclonal Antibody
SKU:
CAB4411
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 473-572 of human CRMP2/DPYSL2 (Q16555).
This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
1808
Clone Number:
ARC1123
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CRMP2/DPYSL2 Rabbit mAb (CAB4411) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
