The CRMP1 Polyclonal Antibody (CAB2705) is specifically designed for research involving CRMP1, also known as Collapsin Response Mediator Protein 1. This antibody, developed using rabbit immunoglobulins, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the CRMP1 protein, this antibody allows for the detection and analysis of CRMP1 in various cell types, making it an ideal tool for studies in neuroscience, cancer research, and other fields.CRMP1 is a cytosolic protein that is involved in axon guidance and neurite outgrowth, playing a crucial role in neuronal development and function.
Dysregulation of CRMP1 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, making it a promising target for research aimed at understanding and treating these conditions. Additionally, CRMP1 has been implicated in cancer progression, with potential implications for cancer therapy development.By utilizing the CRMP1 Polyclonal Antibody in your research, you can further elucidate the role of CRMP1 in various physiological and pathological processes, ultimately contributing to advancements in our understanding of neurobiology, cancer biology, and beyond.
Product Name:
CRMP1 Rabbit Polyclonal Antibody
SKU:
CAB2705
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 460-540 of human CRMP1 (NP_001304.1).
Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle.
Calculated MW:
62kDa
Observed MW:
62kDa
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1400
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat brain, using CRMP1 antibody (CAB2705) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
