The CRLF2 Polyclonal Antibody (CAB10152) is a valuable tool for researchers studying the CRLF2 protein, a cytokine receptor involved in various cellular processes. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CRLF2 protein, this antibody allows for accurate detection and analysis in different cell types, making it ideal for investigations in immunology and cancer research.
CRLF2, also known as cytokine receptor-like factor 2, plays a crucial role in signal transduction and cell growth regulation. Its involvement in these pathways makes it a significant target for studies on diseases such as cancer, inflammatory disorders, and immune-related conditions. Understanding the functions of CRLF2 is essential for developing targeted therapies that can modulate its activity and potentially impact disease progression.
Product Name:
CRLF2 Rabbit Polyclonal Antibody
SKU:
CAB10152
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-231 of human CRLF2 (NP_071431.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
42kDa
Observed MW:
50kDa
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
64109
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CRLF2 antibody (CAB10152) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
