CRLF2 Rabbit Polyclonal Antibody (CAB10152)
- SKU:
- CAB10152
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | CRLF2 Rabbit Polyclonal Antibody |
SKU: | CAB10152 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-231 of human CRLF2 (NP_071431.2). |
Sequence: | QGGA AEGV QIQI IYFN LETV QVTW NASK YSRT NLTF HYRF NGDE AYDQ CTNY LLQE GHTS GCLL DAEQ RDDI LYFS IRNG THPV FTAS RWMV YYLK PSSP KHVR FSWH QDAV TVTC SDLS YGDL LYEV QYRS PFDT EWQS KQEN TCNV TIEG LDAE KCYS FWVR VKAM EDVY GPDT YPSD WSEV TCWQ RGEI RDAC AETP TPPK PKLS K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:1000 |
Synonyms: | CRL2; TSLPR; CRLF2Y; CRLF2 |
Positive Sample: | 293T,Jurkat,Mouse liver,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 42kDa |
Observed MW: | 50kDa |
This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 64109 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |