The CRK-like Protein Polyclonal Antibody (CAB0511) is a valuable tool for researchers studying CRK-like protein, a signaling adaptor protein involved in cell migration and invasion. This antibody, generated in rabbits, demonstrates high specificity and sensitivity for detecting CRK-like protein in human samples, making it ideal for Western blot applications.CRK-like protein is a critical player in signaling pathways that regulate cell growth, survival, and motility. Dysregulation of CRK-like protein has been implicated in various diseases, including cancer, making it a promising target for therapeutic intervention.
By using the CRK-like Protein Polyclonal Antibody, researchers can further elucidate the role of CRK-like protein in disease progression and potentially identify new treatment strategies.Overall, the CRK-like Protein Polyclonal Antibody offers a reliable tool for investigating the function and regulation of CRK-like protein in a variety of biological contexts, providing valuable insights into cellular signaling pathways and potential therapeutic targets.
Product Name:
CRKL Rabbit Polyclonal Antibody
SKU:
CAB0511
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 201-300 of human CRKL (NP_005198.1).
cytosol, extrinsic component of postsynaptic membrane, neuromuscular junction, nucleoplasm
Calculated MW:
34kDa
Observed MW:
34kDa
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Purification Method:
Affinity purification
Gene ID:
1399
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CRKL antibody (CAB0511) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
