CRK/CRKII Rabbit Monoclonal Antibody (CAB9577)
- SKU:
- CAB9577
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | CRK/CRKII Rabbit Monoclonal Antibody |
SKU: | CAB9577 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CRK/CRKII (P46108). |
Sequence: | MAGN FDSE ERSS WYWG RLSR QEAV ALLQ GQRH GVFL VRDS STSP GDYV LSVS ENSR VSHY IINS SGPR PPVP PSPA QPPP GVSP SRLR IGDQ EFDS LPAL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | p38; CRKII; CRK/CRKII |
Positive Sample: | 293T,A549,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm. |
Calculated MW: | 34kDa |
Observed MW: | 37kDa |
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Purification Method: | Affinity purification |
Gene ID: | 1398 |
Clone Number: | ARC1644 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |