CRK/CRKII Rabbit Polyclonal Antibody (CAB1604)
- SKU:
- CAB1604
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | CRK/CRKII Rabbit Polyclonal Antibody |
SKU: | CAB1604 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-304 of human CRK/CRKII (NP_058431.2). |
Sequence: | MAGN FDSE ERSS WYWG RLSR QEAV ALLQ GQRH GVFL VRDS STSP GDYV LSVS ENSR VSHY IINS SGPR PPVP PSPA QPPP GVSP SRLR IGDQ EFDS LPAL LEFY KIHY LDTT TLIE PVSR SRQG SGVI LRQE EAEY VRAL FDFN GNDE EDLP FKKG DILR IRDK PEEQ WWNA EDSE GKRG MIPV PYVE KYRP ASAS VSAL IGGN QEGS HPQP LGGP EPGP YAQP SVNT PLPN LQNG PIYA RVIQ KRVP NAYD KTAL ALEV GELV KVTK INVS GQWE GECN GKRG HFPF THVR LLDQ QNPD EDFS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | p38; CRKII; CRK/CRKII |
Positive Sample: | A-549,MCF7,BT-474,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm. |
Calculated MW: | 34kDa |
Observed MW: | 37kDa |
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Purification Method: | Affinity purification |
Gene ID: | 1398 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |