CRISP3 Antibody (PACO16075)
- SKU:
- PACO16075
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CRISP3 Antibody (PACO16075)
The CRISP3 Polyclonal Antibody (PAC016075) is a research tool designed for studying CRISP3, a protein involved in various physiological processes, including immune modulation and reproductive functions. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CRISP3 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an ideal choice for research in immunology and reproductive biology.
CRISP3, also known as cysteine-rich secretory protein 3, is known for its roles in immune response regulation and sperm maturation. Its involvement in these processes makes it a valuable target for studying conditions related to fertility and immune dysfunction. By elucidating the functions of CRISP3, researchers can gain valuable insights into diseases such as infertility, autoimmune disorders, and inflammatory conditions, leading to the development of novel therapeutic strategies.
| Antibody Name: | CRISP3 Antibody (PACO16075) |
| Antibody SKU: | PACO16075 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human CRISP3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16075(CRISP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16075(CRISP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins which may play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. AEG is a sperm surface protein involved in the fusion of egg and sperm. Although CRISP-1 (also designated AEG-like protein, ARP, cysteine-rich secretory protein-1 or AEG-related protein) is not the ortholog of rodent AEG, it resembles AEG in that it is an epididymal secretory glycoprotein that binds to the postacrosomal region of the sperm head. CRISP-1 coats the postacrosomal region of sperm heads as they pass through the epididymis. CRISP-1 is found in all regions of the epididymis, ductus deferens, seminal plasma and sperm. CRISP-3 is expressed in pancreas and prostate tissues and, along with CRISP-1, is expressed in saliva. |
| Synonyms: | cysteine-rich secretory protein 3 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016] |
| UniProt Code: | P54108 |
| NCBI GenInfo Identifier: | 1706135 |
| NCBI Gene ID: | 10321 |
| NCBI Accession: | P54108.1 |
| UniProt Secondary Accession: | P54108 |
| UniProt Related Accession: | P54108 |
| Molecular Weight: | |
| NCBI Full Name: | Cysteine-rich secretory protein 3 |
| NCBI Synonym Full Names: | cysteine rich secretory protein 3 |
| NCBI Official Symbol: | CRISP3Â Â |
| NCBI Official Synonym Symbols: | Aeg2; CRS3; SGP28; CRISP-3; dJ442L6.3Â Â |
| NCBI Protein Information: | cysteine-rich secretory protein 3 |
| UniProt Protein Name: | Cysteine-rich secretory protein 3 |
| UniProt Synonym Protein Names: | Specific granule protein of 28 kDa; SGP28 |
| Protein Family: | |
| UniProt Gene Name: | CRISP3Â Â |
| UniProt Entry Name: | CRIS3_HUMAN |
| Antibodies |
| CRISP3 Antibody (PACO08603) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
CRISP3 Antibody (PACO16074)
€339
CRISP3 Antibody (PACO08603)
€459
Human Cysteine Rich Secretory Protein 3 (CRISP3) ELISA Kit (HUDL00681)
€649
SEZ6 Antibody (PACO64941)
€339
TTC14 Antibody (PACO64997)
€339
OSTN Antibody (PACO64881)
€339