The CRISP3 Antibody (PACO16074) is a valuable tool for researchers studying the CRISP3 protein, which is a member of the cysteine-rich secretory protein (CRISP) family known for its role in various biological processes. This polyclonal antibody, generated in rabbits, specifically targets CRISP3 in human samples and is validated for use in applications such as Western blotting.CRISP3 is implicated in several physiological functions including sperm maturation, immune response modulation, and potentially in cancer progression. Its involvement in these processes makes it a promising target for research in reproductive biology, immunology, and oncology.
The CRISP3 Antibody allows for the detection and analysis of CRISP3 in different cell types, providing valuable insights into its function and potential role in disease development.This antibody is a valuable tool for scientists looking to further understand the role of CRISP3 in health and disease. Its high reactivity and specificity make it an ideal choice for researchers conducting studies in fields such as reproductive health, immunology, and cancer biology. By investigating the function of CRISP3, researchers can potentially uncover new therapeutic targets and pathways for various conditions.
Antibody Name:
CRISP3 Antibody (PACO16074)
Antibody SKU:
PACO16074
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Fusion protein of human CRISP3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16074(CRISP3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16074(CRISP3 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Cysteine-rich secretory proteins (CRISPs) represent a family of evolutionarily conserved proteins which may play a role in the innate immune system and are transcriptionally regulated by androgens in several tissues. AEG is a sperm surface protein involved in the fusion of egg and sperm. Although CRISP-1 (also designated AEG-like protein, ARP, cysteine-rich secretory protein-1 or AEG-related protein) is not the ortholog of rodent AEG, it resembles AEG in that it is an epididymal secretory glycoprotein that binds to the postacrosomal region of the sperm head. CRISP-1 coats the postacrosomal region of sperm heads as they pass through the epididymis. CRISP-1 is found in all regions of the epididymis, ductus deferens, seminal plasma and sperm. CRISP-3 is expressed in pancreas and prostate tissues and, along with CRISP-1, is expressed in saliva.
Synonyms:
cysteine-rich secretory protein 3
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
