The CRIM1 Antibody (PAC019511) is a valuable tool for researchers studying CRIM1, a cell surface protein with roles in development and disease. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is optimized for use in Western blotting applications. By binding specifically to the CRIM1 protein, this antibody enables scientists to detect and analyze CRIM1 expression in various cell types, making it a versatile tool for immunology and cancer research.CRIM1, also known as cysteine-rich motor neuron 1 protein, is involved in diverse biological processes including cell growth, differentiation, and migration.
Dysregulation of CRIM1 has been implicated in several diseases such as cancer, cardiovascular disorders, and developmental abnormalities. Investigating the function of CRIM1 is essential for gaining insights into its role in health and disease, and may lead to the development of novel therapeutic strategies targeting this protein.Overall, the CRIM1 Antibody (PAC019511) offers researchers a reliable and sensitive tool for investigating the functions and mechanisms of CRIM1, paving the way for advancements in biomedical research and drug discovery.
Antibody Name:
CRIM1 Antibody (PACO19511)
Antibody SKU:
PACO19511
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human CRIM1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19511(CRIM1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19511(CRIM1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor β family, such as bone morphogenetic proteins.
May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]
