The CRHR1 Polyclonal Antibody (CAB8409) is specifically designed for research involving the CRHR1 protein, which is a cell surface receptor involved in stress responses and regulation of the hypothalamic-pituitary-adrenal (HPA) axis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CRHR1 protein, researchers can gain insights into the role of this receptor in various cellular processes related to stress and hormone regulation.The CRHR1 receptor is known to be a key player in the body's response to stress, playing a crucial role in the release of hormones like cortisol in times of stress. Dysregulation of the CRHR1 receptor has been linked to various stress-related disorders such as anxiety, depression, and PTSD.
By studying the activity and expression of CRHR1, researchers can uncover important mechanisms underlying stress-related conditions and potentially identify novel therapeutic targets for these disorders.Overall, the CRHR1 Polyclonal Antibody (CAB8409) is a valuable tool for researchers interested in studying the CRHR1 receptor and its implications in stress-related disorders. Its high specificity and reactivity make it a reliable choice for investigating the role of CRHR1 in cellular signaling pathways and identifying potential therapeutic strategies for managing stress-related conditions.
Product Name:
CRHR1 Rabbit Polyclonal Antibody
SKU:
CAB8409
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-120 of human CRHR1 (NP_001138618.1).
This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene.
Purification Method:
Affinity purification
Gene ID:
1394
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CRHR1 antibody (CAB8409) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
