The CRHBP Polyclonal Antibody (CAB6568) is a valuable tool for researchers studying CRHBP, a protein involved in the regulation of the stress response and mood disorders. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to CRHBP, researchers can detect and analyze the protein in various cell types, making it an excellent choice for studies in neuroscience, endocrinology, and mental health research.CRHBP, also known as corticotropin-releasing hormone-binding protein, is essential for modulating the effects of stress hormones like corticotropin-releasing hormone (CRH).
Dysregulation of CRHBP has been implicated in conditions such as depression, anxiety, and post-traumatic stress disorder. By studying the function and expression of CRHBP, researchers can gain insights into the underlying mechanisms of these disorders and potentially identify new therapeutic targets for treatment.Overall, the CRHBP Polyclonal Antibody (CAB6568) offers researchers a powerful tool for investigating the role of CRHBP in stress response regulation and mental health disorders, with implications for the development of novel treatment strategies.
Product Name:
CRHBP Rabbit Polyclonal Antibody
SKU:
CAB6568
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-322 of human CRHBP (NP_001873.2).
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.
Purification Method:
Affinity purification
Gene ID:
1393
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat brain, using CRHBP Rabbit pAb (CAB6568) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
