The CRELD2 Polyclonal Antibody (PACO16072) is a valuable tool for researchers studying the CRELD2 protein, which is involved in various biological processes such as cell adhesion, embryonic development, and tissue remodeling. This antibody, generated using rabbit immunization, exhibits high specificity for human samples and has been validated for use in Western blot applications.CRELD2, also known as cysteine-rich with EGF-like domains 2, is a key player in cellular processes such as cell proliferation, migration, and differentiation. Its role in embryonic development and tissue homeostasis suggests its potential importance in disease processes, making it a prime target for further investigation in areas such as developmental biology, cancer research, and regenerative medicine.
By utilizing the CRELD2 Polyclonal Antibody, researchers can effectively detect and analyze the presence of CRELD2 in various cell types, enabling a better understanding of its function and potential implications in disease pathology. This antibody is a valuable tool for advancing our knowledge of CRELD2 biology and its potential therapeutic applications.
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO16072(CRELD2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human normal colon tissue, Primary antibody: PACO16072(CRELD2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16072(CRELD2 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The epidermal growth factor (EGF) repeat-containing proteins constitute an expanding family of proteins that are involved in several cellular activities, such as blood coagulation, fibrinolysis, cell adhesion and neural and vertebrate development. CRELD2 (cysteine-rich with EGF-like domains 2) is a 353 amino acid, protein that is ubiquitously expressed and contains two FU domains and two EGF-like domains. Localized to the endoplasmic reticulum and secreted into the cell, CRELD2 interacts with AChR 4, possibly regulating its transport. Human CRELD2 shares 69% amino acid, identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of CRELD2 exist due to alternative splicing events. The gene encoding CRELD2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.
Synonyms:
cysteine-rich with EGF-like domains 2
UniProt Protein Function:
CRELD2: May regulate transport of alpha4-beta2 neuronal acetylcholine receptor. Belongs to the CRELD family. 6 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 22q13.33Molecular Function: protein binding
