The CREBL2 Polyclonal Antibody (PACO08595) is a valuable tool for researchers studying CREBL2, a transcription factor involved in various cellular processes such as metabolism and stress responses. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blotting applications. By targeting the CREBL2 protein, this antibody allows for precise detection and analysis in different cell types, making it ideal for investigations in molecular biology and cell signaling pathways.
CREBL2, also known as cAMP-responsive element-binding protein-like 2, is essential for the regulation of gene expression in response to cellular signals such as cAMP and various stressors. Its role in metabolic pathways and stress adaptation makes it a promising target for research into metabolic disorders, diabetes, and neurodegenerative diseases. Understanding the function of CREBL2 is crucial for developing targeted therapies that can modulate these pathways in disease contexts.
cAMP responsive element binding protein-like 2;CREBL2;MGC117311;MGC138362 ;
UniProt Protein Function:
CREBL2: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor. Belongs to the bZIP family. ATF subfamily.Protein type: Transcription factor; Tumor suppressorChromosomal Location of Human Ortholog: 12p13Cellular Component: nucleusMolecular Function: sequence-specific DNA binding; transcription factor activityBiological Process: cell cycle; cell differentiation; positive regulation of fat cell differentiation; positive regulation of glucose import; positive regulation of lipid biosynthetic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription, DNA-dependent; protein stabilization; signal transduction; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
