The CREBBP Polyclonal Antibody (CAB17096) is a valuable tool for researchers studying CREBBP, a transcriptional coactivator with histone acetyltransferase activity that plays a crucial role in gene expression regulation. This antibody, generated in rabbits, specifically targets the CREBBP protein and has been validated for use in Western blot applications, allowing for the detection and analysis of CREBBP in various cell types.CREBBP, also known as CREB-binding protein, is a key player in epigenetic mechanisms and is involved in the activation of numerous genes that are critical for cell growth, differentiation, and development. Dysregulation of CREBBP has been implicated in various diseases, including cancer, neurological disorders, and developmental abnormalities.
Therefore, studying the function and activity of CREBBP is essential for understanding its role in these pathological conditions and potentially identifying new therapeutic targets.By using the CREBBP Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms underlying CREBBP function and its implications in disease pathology. This antibody is a reliable tool for investigating CREBBP biology in a research setting, making it an essential component for studies in the fields of molecular biology, cancer research, and epigenetics.
Product Name:
CREBBP Rabbit Polyclonal Antibody
SKU:
CAB17096
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-445 of mouse CREBBP (NP_001020603.1).
Enables several functions, including DNA-binding transcription factor binding activity; TFIIB-class transcription factor binding activity; and disordered domain specific binding activity. Involved in several processes, including cellular response to virus; face morphogenesis; and negative regulation of interferon-beta production. Acts upstream of or within cellular response to hepatocyte growth factor stimulus; germ-line stem cell population maintenance; and regulation of gene expression. Located in chromatin and nucleus. Part of RNA polymerase II transcription regulator complex; histone acetyltransferase complex; and outer kinetochore. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; heart; and skin. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein).
Purification Method:
Affinity purification
Gene ID:
12914
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CREBBP Rabbit pAb (CAB17096) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
