The CREBBP Polyclonal Antibody (CAB14237) is a reliable tool for researchers studying the CREBBP protein, which is involved in regulating gene expression and cell growth. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting CREBBP in human samples, making it suitable for use in Western blot applications.CREBBP, also known as CREB-binding protein, plays a crucial role in various cellular processes, including transcriptional regulation and DNA repair. Dysregulation of CREBBP has been implicated in a variety of diseases, including cancer, neurodevelopmental disorders, and cardiovascular conditions.
By targeting CREBBP with this antibody, researchers can further explore its functions and potential therapeutic applications in these disease contexts.Overall, the CREBBP Polyclonal Antibody is a valuable tool for investigating the role of CREBBP in health and disease, offering researchers a reliable means to study its expression and activity in different experimental setups.
Product Name:
CREBBP Rabbit Polyclonal Antibody
SKU:
CAB14237
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-445 of mouse CREBBP (NP_001020603.1).
Enables several functions, including DNA-binding transcription factor binding activity; TFIIB-class transcription factor binding activity; and disordered domain specific binding activity. Involved in several processes, including cellular response to virus; face morphogenesis; and negative regulation of interferon-beta production. Acts upstream of or within cellular response to hepatocyte growth factor stimulus; germ-line stem cell population maintenance; and regulation of gene expression. Located in chromatin and nucleus. Part of RNA polymerase II transcription regulator complex; histone acetyltransferase complex; and outer kinetochore. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; heart; and skin. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein).
Purification Method:
Affinity purification
Gene ID:
12914
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CREBBP antibody (CAB14237) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
