The CREBBP Polyclonal Antibody (CAB1334) is a valuable tool for researchers studying the CREBBP protein, a transcriptional co-activator involved in gene regulation and chromatin remodeling. This antibody, generated in rabbits, shows high specificity for human samples and has been validated for use in Western blot applications.CREBBP, also known as CREB-binding protein, plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Dysregulation of CREBBP has been implicated in several diseases, including cancer, developmental disorders, and neurological conditions.
Studying the expression and function of CREBBP using this antibody can provide insights into its role in these diseases and potentially lead to the development of targeted therapies.With its high reactivity and specificity, the CREBBP Polyclonal Antibody is a valuable tool for researchers in the fields of molecular biology, oncology, and developmental biology. Its ability to detect and analyze CREBBP protein levels in different cell types makes it a versatile option for a wide range of research applications.
Product Name:
CREBBP Rabbit Polyclonal Antibody
SKU:
CAB1334
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CREBBP (NP_004371.2).
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
1387
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from NIH/3T3 cells, using CREBBP Rabbit pAb (CAB1334) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
