The CREB5 Polyclonal Antibody (CAB14635) is a vital tool for researchers studying CREB5, a transcription factor that plays a key role in regulating gene expression and cell survival. This antibody, developed through rabbit immunization, exhibits high reactivity with human samples and is suitable for use in Western blotting applications. By binding specifically to the CREB5 protein, it allows for precise detection and analysis in a variety of cell types, making it an essential asset for investigations in molecular biology and cancer research.
CREB5, also referred to as cAMP response element-binding protein 5, is involved in diverse cellular processes such as cell growth, differentiation, and apoptosis. Its involvement in gene transcription and cell signaling pathways implicates it in the development of various diseases, including cancer and neurodegenerative disorders. By elucidating the functions of CREB5, researchers can gain crucial insights into disease mechanisms and potentially identify new therapeutic targets for intervention.
Product Name:
CREB5 Rabbit Polyclonal Antibody
SKU:
CAB14635
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 210-380 of human CREB5 (NP_878902.2).
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
9586
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CREB5 antibody (CAB14635) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
