The CREB3L4 Polyclonal Antibody (PAC0526.54) is a valuable tool for researchers studying the CREB3L4 protein, which plays a key role in transcriptional regulation and cellular response to stress. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications.CREB3L4 is a transcription factor that regulates the expression of genes involved in various cellular processes, including cell development, differentiation, and survival. It is known to be activated in response to cellular stress and is implicated in the pathogenesis of certain diseases, making it a promising target for therapeutic intervention.
By using the CREB3L4 Polyclonal Antibody, researchers can accurately detect and analyze the CREB3L4 protein in different cell types, aiding in the investigation of its functional role in health and disease. This antibody is an essential tool for studies in molecular biology, cell biology, and biomedicine, providing valuable insights into the cellular mechanisms governed by CREB3L4.
Antibody Name:
CREB3L4 Antibody (PACO52654)
Antibody SKU:
PACO52654
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 4 protein (13-133AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO52654 at dilution of 1:100.
Background:
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity).
Synonyms:
Cyclic AMP-responsive element-binding protein 3-like protein 4 (cAMP-responsive element-binding protein 3-like protein 4) (Androgen-induced basic leucine zipper protein) (AIbZIP) (Attaching to CRE-like 1) (ATCE1) (Cyclic AMP-responsive element-binding protein 4) (CREB-4) (cAMP-responsive element-binding protein 4) (Transcript induced in spermiogenesis protein 40) (Tisp40) (hJAL) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 4], CREB3L4, AIBZIP CREB4 JAL
UniProt Protein Function:
CREB3L4: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Belongs to the bZIP family. ATF subfamily.Protein type: Transcription factor; Endoplasmic reticulum; Membrane protein, integralChromosomal Location of Human Ortholog: 1q21.3Cellular Component: endoplasmic reticulum; Golgi apparatusBiological Process: positive regulation of transcription from RNA polymerase II promoter
UniProt Protein Details:
NCBI Summary:
This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
