The CREB3L3 Polyclonal Antibody (CAB16655) is a valuable tool for researchers studying CREB3L3, a transcription factor involved in cellular stress response and lipid metabolism. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the CREB3L3 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in molecular biology and metabolic research.
CREB3L3, also known as OASIS, plays a crucial role in the unfolded protein response pathway and has been linked to diseases such as diabetes, obesity, and neurodegenerative disorders. Understanding the function of CREB3L3 is essential for unraveling the mechanisms underlying these conditions and advancing potential therapeutic interventions. The use of the CREB3L3 Polyclonal Antibody in research can contribute to insights that may lead to the development of novel treatments targeting CREB3L3-related pathways.
Product Name:
CREB3L3 Rabbit Polyclonal Antibody
SKU:
CAB16655
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 371-460 of human CREB3L3 (NP_001258924.1).
This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
84699
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using CREB3L3 Rabbit pAb (CAB16655) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
