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CREB3L1 Antibody (PACO13412)

SKU:
PACO13412
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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CREB3L1 Antibody (PACO13412)

The CREB3L1 Polyclonal Antibody (PAC013412) is a valuable tool for researchers studying CREB3L1, a transcription factor involved in cellular stress response and regulation of gene expression. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blotting and immunohistochemistry applications.CREB3L1, also known as OASIS, plays a key role in the unfolded protein response pathway, promoting cell survival under conditions of endoplasmic reticulum stress. Dysregulation of CREB3L1 has been linked to various diseases, including neurodegenerative disorders and cancer.

Research aimed at understanding the function and regulation of CREB3L1 has the potential to uncover new therapeutic targets for these conditions.By utilizing the CREB3L1 Polyclonal Antibody, researchers can investigate the expression and activity of CREB3L1 in different cellular contexts, shedding light on its role in disease pathogenesis and providing insights into potential treatment strategies. This antibody is a valuable asset for studies in molecular biology, cell biology, and medical research, offering reliable detection and analysis of CREB3L1 protein levels.

Antibody Name:CREB3L1 Antibody (PACO13412)
Antibody SKU:PACO13412
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human CREB3L1,OASIS
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:cAMP responsive element binding protein 3-like 1;CREB3L1;OASIS ;
UniProt Protein Function:CREB3L1: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. Belongs to the bZIP family. ATF subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; nucleus

Molecular Function:sequence-specific DNA binding; chromatin binding

Biological Process: transcription, DNA-dependent; unfolded protein response; regulation of bone mineralization

NCBI Summary:The protein encoded by this gene is normally found in the membrane of the endoplasmic reticulum (ER). However, upon stress to the ER, the encoded protein is cleaved and the released cytoplasmic transcription factor domain translocates to the nucleus. There it activates the transcription of target genes by binding to box-B elements. [provided by RefSeq, Jun 2013]
UniProt Code:Q96BA8
NCBI GenInfo Identifier:74751763
NCBI Gene ID:90993
NCBI Accession:Q96BA8.1
UniProt Secondary Accession:Q96BA8,Q8N2D5, Q96CP0,
UniProt Related Accession:Q96BA8
Molecular Weight:519
NCBI Full Name:Cyclic AMP-responsive element-binding protein 3-like protein 1
NCBI Synonym Full Names:cAMP responsive element binding protein 3-like 1
NCBI Official Symbol:CREB3L1  
NCBI Official Synonym Symbols:OASIS  
NCBI Protein Information:cyclic AMP-responsive element-binding protein 3-like protein 1; BBF-2 homolog; old astrocyte specifically-induced substance; cAMP-responsive element-binding protein 3-like protein 1
UniProt Protein Name:Cyclic AMP-responsive element-binding protein 3-like protein 1
UniProt Synonym Protein Names:Old astrocyte specifically-induced substance; OASIS
Protein Family:Cyclic AMP-responsive element-binding protein 3-like protein
UniProt Gene Name:CREB3L1  
UniProt Entry Name:CR3L1_HUMAN

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