The CREB3 Polyclonal Antibody (CAB6567) is a vital tool for research involving CREB3, a transcription factor known for its role in the regulation of gene expression in response to cellular stress. This antibody, developed using rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications.CREB3, also known as cAMP-responsive element-binding protein 3, is a key player in cellular responses to various stress stimuli, including endoplasmic reticulum stress and viral infections. Its involvement in these processes makes it a significant target for studies in cell biology, virology, and disease pathogenesis.
By utilizing the CREB3 Polyclonal Antibody, researchers can effectively detect and analyze the expression of CREB3 in different cell types, aiding in the understanding of its function and potential therapeutic implications. This antibody is well-suited for investigations into conditions such as cancer, viral infections, and neurodegenerative diseases where CREB3 dysregulation has been implicated. Unlock the potential of CREB3 research with the reliable and specific detection provided by this polyclonal antibody.
Product Name:
CREB3 Rabbit Polyclonal Antibody
SKU:
CAB6567
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CREB3 (NP_006359.3).
Cytoplasm, Endoplasmic reticulum membrane, Membrane, Nucleus, Single-pass type II membrane protein.
Calculated MW:
41kDa
Observed MW:
41kDa
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
10488
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CREB3 antibody (CAB6567) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
