The CREB1 Polyclonal Antibody (CAB11989) is a valuable tool for researchers studying the CREB1 protein, a transcription factor involved in various cellular processes such as cell growth, differentiation, and memory formation. This antibody is raised in rabbits and is highly specific for human samples, making it ideal for Western blot applications.CREB1, also known as cAMP response element-binding protein 1, plays a crucial role in gene regulation and is implicated in several diseases including cancer, neurodegenerative disorders, and psychiatric conditions.
By targeting CREB1 with this antibody, researchers can detect and analyze the protein in different cell types, providing insights into its function and potential therapeutic applications.Overall, the CREB1 Polyclonal Antibody (CAB11989) is a valuable tool for researchers interested in studying the molecular mechanisms regulated by CREB1 and its implications in various diseases. Its high reactivity and specificity make it a reliable choice for immunology and cancer research studies.
Product Name:
CREB1 Rabbit Polyclonal Antibody
SKU:
CAB11989
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human CREB1 (NP_604391.1).
WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
CREB; CREB-1; CREB1
Positive Sample:
HeLa,Jurkat,C6
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
35kDa
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
1385
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CREB1 Rabbit pAb (CAB11989) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
