The CREB1 Polyclonal Antibody (CAB11064) is a valuable tool for researchers studying CREB1, a transcription factor involved in various cellular processes, including cell growth, differentiation, and survival. This antibody, produced in rabbits, is highly specific to human samples and is suitable for use in Western blot and other research applications. By binding to the CREB1 protein, this antibody enables the detection and analysis of CREB1 expression in different cell types, making it an essential component for studies in molecular biology and neuroscience.CREB1, also known as cAMP response element-binding protein 1, plays a crucial role in gene regulation and is implicated in the pathogenesis of various diseases, including cancer, neurodegenerative disorders, and mental health conditions.
By investigating the function of CREB1, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify new therapeutic targets. The CREB1 Polyclonal Antibody is a valuable tool for studying the role of CREB1 in health and disease, paving the way for advancements in personalized medicine and targeted therapies.
Product Name:
CREB1 Rabbit Polyclonal Antibody
SKU:
CAB11064
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human CREB1 (NP_604391.1).
WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
CREB; CREB-1; CREB1
Positive Sample:
HeLa,U-251MG,Mouse brain
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
35kDa
Observed MW:
43kDa
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
1385
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CREB1 Rabbit pAb (CAB11064).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
