The CRB2 Antibody (PAC046586) is a powerful tool for researchers studying the CRB2 protein, a key player in cell polarity and tissue morphogenesis. This polyclonal antibody, produced in rabbit hosts, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.CRB2, also known as Crumbs homolog 2, is essential for the formation and maintenance of epithelial cell polarity, which is crucial for proper tissue organization and function. Dysregulation of CRB2 has been implicated in a variety of diseases, including cancer and developmental disorders. By targeting the CRB2 protein with this antibody, researchers can investigate its role in cell polarity processes and potentially discover new therapeutic strategies for related conditions.
With its specificity and reliability, the CRB2 Antibody (PAC046586) is a valuable tool for advancing research in cell biology, developmental biology, and cancer biology. Whether studying normal cellular processes or disease-related mechanisms, this antibody provides a reliable means of detecting and analyzing CRB2 protein expression in various cell types, enhancing the understanding of its functions and implications in human health.
Antibody Name:
CRB2 Antibody (PACO46586)
Antibody SKU:
PACO46586
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:1000-1:2000
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein crumbs homolog 2 protein (253-483AA)
IHC image of PACO46586 diluted at 1:1600 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system..
Background:
May play a role in polarized cells morphogenesis.
Synonyms:
Protein crumbs homolog 2 (Crumbs-like protein 2), CRB2
UniProt Protein Function:
CRB2: May play a role in polarized cells morphogenesis. Belongs to the Crumbs protein family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 9q33.3Cellular Component: protein complex; integral to membrane; plasma membrane; lipid raftMolecular Function: enzyme binding; aspartic-type endopeptidase inhibitor activity; calcium ion bindingBiological Process: somitogenesis; mesoderm formation; notochord formation; maintenance of epithelial cell polarity; positive regulation of BMP signaling pathwayDisease: Ventriculomegaly With Cystic Kidney Disease; Focal Segmental Glomerulosclerosis 9
