null

Cr2 Antibody (PACO25905)

SKU:
PACO25905
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

Cr2 Antibody (PACO25905)

The CR2 Monoclonal Antibody (PAC025905) is a valuable tool for researchers studying CR2, a cell surface molecule involved in immune regulation and B cell activation. This antibody, developed using monoclonal technology, specifically targets human samples and has been validated for use in various applications including immunohistochemistry and flow cytometry. By binding to the CR2 protein, this antibody enables precise detection and analysis in different cell types, making it an ideal choice for studies in immunology and cancer research.

CR2, also known as complement receptor 2, plays a crucial role in the activation and regulation of B cells, thereby influencing immune responses and antibody production. Its involvement in the immune system makes it a promising target for research focused on understanding diseases such as cancer, autoimmune disorders, and infectious diseases. Investigating the function of CR2 is essential for developing targeted therapies that manipulate immune responses for therapeutic purposes.

Antibody Name:Cr2 Antibody (PACO25905)
Antibody SKU:PACO25905
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Mouse
Immunogen:Recombinant Mouse Complement receptor type 2 protein (729-963AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Receptor for complement C3d. Participates in B lymphocytes activation.
Synonyms:Complement receptor type 2 (Cr2) (Complement C3d receptor) (CD antigen CD21), Cr2
UniProt Protein Function:CR2: Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Genetic variations in CR2 are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Defects in CR2 are the cause of immunodeficiency, common variable, type 7 (CVID7). A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. Belongs to the receptors of complement activation (RCA) family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, misc.Cellular Component: membrane; integral to membrane; receptor complex; external side of plasma membraneMolecular Function: complement binding; protein binding; complement receptor activity; protein homodimerization activity; DNA binding; receptor activityBiological Process: B cell proliferation; B cell activation; immune system process; complement receptor mediated signaling pathway; B cell differentiation; innate immune response; complement activation, classical pathway
UniProt Protein Details:
NCBI Summary:
UniProt Code:P19070
NCBI GenInfo Identifier:117316
NCBI Gene ID:12902
NCBI Accession:P19070.1
UniProt Secondary Accession:P19070
UniProt Related Accession:P19070
Molecular Weight:Predicted Molecular Mass: 26.4kDaAccurate Molecular Mass: 31kDa as determined by SDS-PAGE reducing conditions.
NCBI Full Name:Complement receptor type 2
NCBI Synonym Full Names:complement receptor 2
NCBI Official Symbol:Cr2  
NCBI Official Synonym Symbols:Cr1; C3DR; CD21; CD35; Cr-1; Cr-2  
NCBI Protein Information:complement receptor type 2; complement C3d receptor; complement receptor type 1; expressed in B lymphocytes
UniProt Protein Name:Complement receptor type 2
UniProt Synonym Protein Names:Complement C3d receptor
Protein Family:Complement receptor
UniProt Gene Name:Cr2  
UniProt Entry Name:CR2_MOUSE

Related Products