The CPZ Polyclonal Antibody (PAC04986) is a valuable tool for researchers studying the CPZ protein, which is involved in various cellular processes including autophagy, lysosomal function, and neurological disorders. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.CPZ, also known as Carboxypeptidase Z, is a zinc metallopeptidase enzyme that plays a crucial role in the cleavage of targeted proteins and peptides. Dysregulation of CPZ has been implicated in diseases such as Alzheimer's, Parkinson's, and lysosomal storage disorders.
Research on CPZ function and expression can provide valuable insight into potential therapeutic targets for these conditions.By utilizing the CPZ Polyclonal Antibody, researchers can effectively detect and analyze CPZ levels in various cell types, aiding in the understanding of its role in disease pathology. This antibody is a valuable tool for studies in neurobiology, lysosomal biology, and neurodegenerative diseases, providing essential information for the development of novel treatment strategies.
Antibody Name:
Cpz Antibody (PACO49486)
Antibody SKU:
PACO49486
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Rat
Immunogen:
Recombinant Rat Carboxypeptidase Z protein (21-652AA)
Western Blot. Positive WB detected in: HEK293 whole cell lysate, A549 whole cell lysate, U87 whole cell lysate. All lanes: CPZ antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 74 kDa. Observed band size: 74, 59 kDa..
Background:
Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing (By similarity).
Synonyms:
Carboxypeptidase Z (CPZ) (EC 3.4.17), Cpz
UniProt Protein Function:
CPZ: Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing (By similarity)Protein type: EC 3.4.17.-; Extracellular matrix; Protease; Secreted; Secreted, signal peptideCellular Component: extracellular spaceMolecular Function: metallocarboxypeptidase activity; serine carboxypeptidase activityBiological Process: peptide metabolic process; protein processing
UniProt Protein Details:
NCBI Summary:
mouse homolog is a metallocarboxypeptidases and may have a role in Wnt signaling [RGD, Feb 2006]
