The CPOX Polyclonal Antibody (CAB3807) is a valuable tool for researchers studying the enzyme coproporphyrinogen oxidase (CPOX), which plays a crucial role in heme biosynthesis. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for a variety of applications such as Western blotting and immunohistochemistry.CPOX is essential for the production of heme, a molecule involved in various biological processes including oxygen transport, energy production, and drug metabolism. Dysregulation of CPOX activity has been linked to diseases such as porphyria, a group of metabolic disorders characterized by the accumulation of heme precursors.
By using the CPOX Polyclonal Antibody, researchers can accurately detect and quantify CPOX levels in different tissues and cell types, allowing for a better understanding of its role in heme biosynthesis and its potential implications in disease development. This antibody is a valuable tool for those studying heme metabolism, porphyria, and related conditions, providing insights that may lead to the development of novel therapeutic strategies.
Product Name:
CPOX Rabbit Polyclonal Antibody
SKU:
CAB3807
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 111-454 of human CPOX (NP_000088.3).
The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).
Purification Method:
Affinity purification
Gene ID:
1371
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CPOX antibody (CAB3807) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
