The CPNE8 Polyclonal Antibody (PACO8574) is a valuable tool for researchers studying CPNE8, a calcium-dependent phospholipid-binding protein involved in various cellular processes. This antibody, derived from rabbit serum, exhibits high specificity and reactivity towards human samples, making it suitable for use in Western blot applications. By targeting the CPNE8 protein, this antibody enables accurate detection and analysis in different cell types, making it an excellent choice for investigations in cell biology and signal transduction pathways.
CPNE8 is known to play a crucial role in membrane dynamics and intracellular signaling, making it a promising target for research in areas such as neurobiology, cell trafficking, and lipid metabolism. Understanding the functions and interactions of CPNE8 can provide insights into its potential involvement in diseases like neurological disorders and cancer. By studying CPNE8 with this antibody, researchers can uncover new therapeutic targets and pathways for drug development in these fields.
CPNE8: a member of the copine protein family with calcium-dependent phospholipid binding properties. Copines are ubiquitously expressed, phospholipid-binding proteins that have been conserved through evolution. Highest expression of CPNE8 mRNA is seen in the prostate, heart, and brain. Fusion to AML1 in a t(12;21) translocation causes aggressive acute myelogenous leukemia. Two alternatively spliced isoforms have been described.Protein type: Unknown functionChromosomal Location of Human Ortholog: 12q12
UniProt Protein Details:
NCBI Summary:
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
