The CPA5 Polyclonal Antibody (PACO22237) is a valuable tool for researchers studying CPA5, a protease involved in the activation of trypsinogen to trypsin in the pancreas. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the CPA5 protein, this antibody enables detection and analysis in various cell types, making it ideal for studying pancreatic function and diseases such as pancreatitis and pancreatic cancer.
CPA5 is a crucial player in the regulation of pancreatic enzyme activation, making it a potential target for therapeutic interventions in pancreatic diseases. Understanding the role of CPA5 in pancreatic function and disease pathology is essential for developing effective treatments and improving patient outcomes. Researchers in the fields of molecular biology, biochemistry, and gastroenterology will find this antibody indispensable for their studies on CPA5 and its implications in pancreatic health.
Antibody Name:
CPA5 Antibody (PACO22237)
Antibody SKU:
PACO22237
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human CPA5.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from 293 cells, using CPA5 antibody.
Background:
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002 [PubMed 11836249]).[supplied by OMIM, Mar 2008]
