The COX7A2/P2 (COX7A2) Antibody (PACO03468) is a valuable tool for researchers studying the role of COX7A2 in cellular metabolism and energy production. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It targets the COX7A2 protein, enabling precise detection and analysis in a variety of cell types, making it ideal for investigations in biochemistry and mitochondrial biology.COX7A2, a subunit of cytochrome c oxidase (complex IV) in the mitochondrial respiratory chain, is essential for oxidative phosphorylation and ATP production.
Dysregulation of COX7A2 has been linked to metabolic disorders and mitochondrial dysfunction, making it a promising target for research into diseases such as diabetes, neurodegenerative disorders, and cancer. Understanding the function of COX7A2 is crucial for the development of therapies aimed at maintaining mitochondrial health and energy balance in various pathological conditions.
Antibody Name:
COX7A2P2/COX7A2 Antibody
Antibody SKU:
PACO03468
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the N-terminal region of human COX7a2/3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
COX7A2P2; COX7A3; COX7AL2; COX7AP2; Putative cytochrome c oxidase subunit 7A3; mitochondrial; Cytochrome c oxidase subunit VIIa 3; COX7A2; COX7AL; Cytochrome c oxidase subunit 7A2, mitochondrial; Cytochrome c oxidase subunit VIIa-liver/hear
UniProt Protein Function:
COX7A2: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIIa family.Protein type: Energy Metabolism - oxidative phosphorylation; Mitochondrial; EC 1.9.3.1; OxidoreductaseChromosomal Location of Human Ortholog: 6q12Cellular Component: mitochondrial respiratory chainMolecular Function: cytochrome-c oxidase activity
UniProt Protein Details:
NCBI Summary:
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]
