The COX7A2P2 Polyclonal Antibody (PAC02325) is specifically designed for research involving COX7A2P2, a protein encoded by the COX7A2L gene. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the COX7A2P2 protein, researchers can detect and analyze its expression in various cell types, making it ideal for studies in mitochondrial biology and metabolic research.COX7A2P2 is a subunit of cytochrome c oxidase, an essential enzyme in the electron transport chain responsible for producing ATP in mitochondria. Dysfunction in cytochrome c oxidase and its subunits has been implicated in various metabolic disorders and mitochondrial diseases.
Therefore, studying the expression and function of COX7A2P2 can provide valuable insights into mitochondrial function and its impact on cellular metabolism.Researchers in the fields of biochemistry, molecular biology, and mitochondrial physiology can benefit from using the COX7A2P2 Polyclonal Antibody in their research to further understand the role of this protein in cellular energy production and mitochondrial function. By targeting COX7A2P2, researchers can uncover potential therapeutic targets for mitochondrial disorders and metabolic diseases.
Synthesized peptide derived from internal of human COX7S/A2.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from rat heart cells, using COX7S/A2 antibody.
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using COX7S/A2 antibody.
Synonyms:
Cytochrome c oxidase subunit VIIa 3; mitochondrial [Precursor]; COX7AP2; COX7A3; COX7AL2
UniProt Protein Function:
COX7A2: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Belongs to the cytochrome c oxidase VIIa family.Protein type: Energy Metabolism - oxidative phosphorylation; Mitochondrial; EC 1.9.3.1; OxidoreductaseChromosomal Location of Human Ortholog: 6q12Cellular Component: mitochondrial respiratory chainMolecular Function: cytochrome-c oxidase activity
UniProt Protein Details:
NCBI Summary:
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]
