COX7A2L Rabbit Polyclonal Antibody (CAB8298)
- SKU:
- CAB8298
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | COX7A2L Rabbit Polyclonal Antibody |
SKU: | CAB8298 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human COX7A2L (NP_004709.2). |
Sequence: | MYYK FSGF TQKL AGAW ASEA YSPQ GLKP VVST EAPP IIFA TPTK LTSD STVY DYAG KNKV PELQ KFFQ KADG VPVY LKRG LPDQ MLYR TTMA LTVG GTIY CLIA LYMA SQPK NK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | EB1; SCAF1; SCAFI; SIG81; COX7AR; COX7RP; COX7A2L |
Positive Sample: | HeLa,MCF7,Mouse liver,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion inner membrane. |
Calculated MW: | 13kDa |
Observed MW: | 13kDa |
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 9167 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |