The COX7A2 Polyclonal Antibody (CAB8406) is a valuable tool for researchers studying the COX7A2 protein, a subunit of cytochrome c oxidase (complex IV) in the mitochondrial respiratory chain. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for Western blot applications. By binding specifically to the COX7A2 protein, this antibody enables the detection and analysis of this critical component in various cell types.COX7A2 is involved in the regulation of oxidative phosphorylation and energy metabolism within the cell. Dysfunction of COX7A2 has been linked to various diseases, including mitochondrial disorders and metabolic conditions.
By studying the activity and function of COX7A2, researchers can gain insights into the molecular mechanisms underlying these pathological conditions and potentially identify novel therapeutic targets.This COX7A2 Polyclonal Antibody is a valuable tool for investigating the role of COX7A2 in mitochondrial function, energy production, and related disease processes. Its specificity and sensitivity make it an essential reagent for studies in molecular biology, biochemistry, and mitochondrial medicine.
Product Name:
COX7A2 Rabbit Polyclonal Antibody
SKU:
CAB8406
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 33-115 of human COX7A2 (NP_001856.2).
Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14.
Purification Method:
Affinity purification
Gene ID:
1347
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using COX7A2 antibody (CAB8406) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
