The COX6C Polyclonal Antibody (CAB16250) is a valuable tool for researchers studying the COX6C protein, a subunit of cytochrome c oxidase, an essential enzyme in the electron transport chain. This antibody, derived from rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the COX6C protein, this antibody allows for the detection and analysis of this important mitochondrial protein in various cell types.COX6C plays a critical role in the electron transport chain, facilitating the conversion of oxygen to water and ultimately producing ATP, the energy currency of the cell.
Dysregulation of COX6C has been implicated in various diseases, including mitochondrial disorders and cancer. Therefore, studying the expression and function of COX6C is essential for understanding mitochondrial function and its role in disease progression.Overall, the COX6C Polyclonal Antibody (CAB16250) is a valuable tool for researchers investigating mitochondrial function, energy metabolism, and diseases associated with mitochondrial dysfunction. Its high specificity and sensitivity make it an ideal choice for studies in biochemistry, cell biology, and cancer research.
Product Name:
COX6C Rabbit Polyclonal Antibody
SKU:
CAB16250
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-75 of human COX6C (NP_004365.1).
mitochondrial inner membrane, mitochondrial respiratory chain complex IV, mitochondrion
Calculated MW:
9kDa
Observed MW:
Refer to figures
Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12.
Purification Method:
Affinity purification
Gene ID:
1345
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of NIH/3T3 cells using COX6C Rabbit pAb (CAB16250) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
